Co-creator of AstraZeneca COVID shot defends safety amid clot concerns | Inquirer News

Co-creator of AstraZeneca COVID shot defends safety amid clot concerns

/ 03:29 AM April 24, 2021

Professor Adrian Hill to members of the media at The Jenner Institute in Oxford, England January 16, 2015. REUTERS/Eddie Keogh/File Photo

Professor Adrian Hill (REUTERS/Eddie Keogh/File Photo)

One of the Oxford scientists who co-developed AstraZeneca’s COVID-19 vaccine defended its safety on Friday and said he was not worried that some countries had opted to restrict its use amid concerns about a possible link to very rare side effects.

Adrian Hill, director of the Oxford University’s Jenner Institute, said teams around the world were working to pin down any potential mechanism for what might be causing the blood clots, using real world data now that so many shots have been administered.

Article continues after this advertisement

He agreed with medicines regulators in Britain, and Europe, and with World Health Organization experts, that the risk-benefit balance for the coronavirus shot favoured its use.

FEATURED STORIES

“If some countries choose to use one (COVID) vaccine, there will be more of the other vaccines for other countries,” Hill told Reuters. “We don’t see this as a huge issue.”

More than a dozen European countries had suspended use of AstraZeneca’s COVID-19 vaccine, called Vaxzevria, amid reports of cases of the clots combined with low platelets in a very small number of people who had received it. Many countries have resumed using the shot, but with some restrictions.

Article continues after this advertisement

After reviewing the safety reports, the European Medicines Agency (EMA) regulator said that while there was a possible link, a direct causal link had not been established and the vaccine’s benefits in preventing severe COVID-19 disease were substantial.

Article continues after this advertisement

Asked whether he was surprised by the reports of blood clot cases occurring in Britain, Norway, Germany and other countries that have been rolling out Vaxzevria, Hill said such extremely rare side effects would not have emerged even in large-scale trials involving tens of thousands of participants.

Article continues after this advertisement

“Nobody can detect something that occurs in one in 300,000 – and maybe causes death in about 1 in a million – if you’re doing studies of the order of 10,000 to 20,000 vaccines,” he said.

“These very, very rare side effects are very hard to pick up with any vaccine. What’s good is that we can now pick these up – because the data linkage infrastructure in the UK and many other countries is able to do this remarkably quickly.”

Article continues after this advertisement

AstraZeneca’s vaccine uses a non-replicating chimpanzee adenovirus vector to deliver instructions for making coronavirus spike proteins into cells to produce an immune response.

Hill said the potential mechanism behind any possible link between the vaccine and the rare blood clot cases was “a matter of intense research by many groups around the world”, including teams at the Jenner Institute and at AstraZeneca.

Your subscription could not be saved. Please try again.
Your subscription has been successful.

Subscribe to our daily newsletter

By providing an email address. I agree to the Terms of Use and acknowledge that I have read the Privacy Policy.

“It may or may not take a long time to figure out,” he said. “I think we’ll be able to do it reasonably quickly and hopefully come up with an immunisation regimen or approach that effectively completely avoids this issue. But we need to … learn more before that.”

TAGS: AstraZenaca, blood clot, COVID-19 Vaccine, hill

Your subscription could not be saved. Please try again.
Your subscription has been successful.

Subscribe to our newsletter!

By providing an email address. I agree to the Terms of Use and acknowledge that I have read the Privacy Policy.

© Copyright 1997-2024 INQUIRER.net | All Rights Reserved

This is an information message

We use cookies to enhance your experience. By continuing, you agree to our use of cookies. Learn more here.