Police officer Ankush Shinde says the engine and four coaches jumped the tracks Sunday near Roha station, 110 kilometers (70 miles) south of Mumbai.
Railway spokesman Anil Kumar Saxena says the rescue operation is underway as two of the derailed coaches tilted on one side.
The cause of the accident was not immediately known.
Railway accidents are common in India, which has one of the world’s largest train networks and serves 20 million passengers a day. Most collisions are blamed on poor maintenance and human error.
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