Many in US seek weight loss drug alternatives | Inquirer News

Many in US seek weight loss drug alternatives

/ 04:58 AM December 05, 2023

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WASHINGTON — Like many Americans struggling to lose weight, Marissa Montanino felt compelled to try Ozempic or one of the other new so-called “wonder drugs” described as revolutionary in the fight against obesity.

“I would work out sometimes three times a day, I was doing hours worth of classes. I was eating really, really clean … and nothing was changing” the 36-year-old esthetician told Agence France-Presse (AFP) in a recent interview.


“I heard about Ozempic for a while and then you start to see other people doing it like celebrities and then dropping weight super fast,” she said.


Cost, supply

Fearing gastrointestinal issues, a side effect of the drugs, Montanino sought reassurance from clients at her studio and in Facebook support groups.

Ultimately deciding to take the leap, Montanino was not prescribed Ozempic, made by Danish drugmaker Novo Nordisk, but rather “compounded” semaglutide.

It’s an option many in the United States are turning to over cost or supply problems with the brand name drugs—but which experts and officials have flagged for possible risks.

Over 40 percent of Americans suffer from obesity, reflecting a major health crisis and the massive market for new Ozempic-type drugs.

With their “groundbreaking” effectiveness, the drugs will be “the first line therapy for people who are obese,” research physician Samuel Klein of Washington University in St. Louis told AFP.

Soaring demand

Semaglutide is the active ingredient in both Ozempic— approved as a diabetes treatment in 2017—and Novo Nordisk’s Wegovy, which gained authorization as an obesity medicine in 2021.


In addition to the millions of diabetic and obese patients seeking out the drugs, countless others without severe health issues are asking doctors for “off-label” prescriptions.

Celebrities, including Elon Musk, have also said they take the drugs to shed pounds—fueling skyrocketing interest.

“The major problem is that it is now difficult to get the medications,” said Klein. “There’s not enough medication being made.”

The US Food and Drug Administration (FDA) classifies semaglutide and tirzepatide—the compound used by Eli Lilly in its drugs Mounjaro and Zepbound—as currently “in shortage.”

The designation means some restrictions may be lifted, allowing the compounding of drugs that are “essentially copies of approved drugs,” the FDA says.

Compounding, the creation of custom drugs, has historically been used when a patient has an allergy to a medicine’s component.

Obesity specialist Andrea Coviello told AFP she is concerned about patients taking compounded weight loss drugs, often ordered online.

Though some of her patients who say they’ve tried the compounded drugs lost weight, it’s “unclear what these patients are actually receiving,” the UNC School of Medicine professor and physician said.

Montanino, who is just over 5 feet (1.53 meters) tall, says that in less than six months using the weekly injections, she has gone down from 157 pounds (71.2 kilograms) to around 130. Her target is 125.


US authorities warn that “compounded drugs pose a higher risk to patients than FDA-approved drugs” because they “do not undergo FDA premarket review for safety, effectiveness, or quality.”

Without further details, it says it has “received adverse event reports after patients used compounded semaglutide.”

An online search for compounded weight loss drugs produces handfuls of retailers offering to ship the medicine by mail.

Advertised prices are much lower than the brand name sticker price, but not necessarily cheaper than when insurance covers it.

Montanino said she initially paid $300 for a three-month supply, but as the dosage increases over time it could eventually become $300 per month.

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Given the booming demand for the drugs, it is unclear when they may come off the shortage list.

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