Scientists study autistic mice for disease clues

WASHINGTON—US scientists said Monday they have engineered autistic mice by deleting a cluster of their genes in the hopes that the research may fuel advances in diagnosis and treatment for humans.

Previous studies have suggested genetic causes could be to blame for the developmental disorder, which can cause social awkwardness, repetitive movements, sensitivity to certain lights and sounds, as well as behavioral problems.

Some children with autism have a small deletion on chromosome 16, affecting 27 genes, so scientists at Cold Spring Harbor Laboratory in New York tried to alter mice so they would have the same genetic mutation.

“The idea that this deletion might be causing autism was exciting,” said professor Alea Mills, co-author of the study that appears in the Proceedings of the National Academy of Sciences.

“So we asked whether clipping out the same set of genes in mice would have any effect.”

It turned out that the altered mice showed behaviors similar to those seen in autistic people — hyperactivity, trouble sleeping, repetitive movements and difficulty adapting to new environments.

“Mice with the deletion acted completely different from normal mice,” said co-author Guy Horev.

Researchers also found that about half the autistic mice died shortly after birth. Future studies could shed light on whether the genetic deficit could be linked to unexplained infant death, the study said.

By closely examining the mice brains with MRI scans, researchers have been able to identify which regions are altered in the autistic mice.

That knowledge could help scientists determine the physiological basis for autism, which affects about one percent of children in the United States, and possibly lead to earlier diagnosis and treatment.

Children who have autism, a range of disorders linked to abnormal brain chemistry, are typically diagnosed by age three. Boys are three to four times more likely to have autism than girls.